Glucosylation of cinobufagin by cultured suspension cells of Catharanthus roseus

✍ Scribed by Min Ye; Jungui Dai; Hongzhu Guo; Yajun Cui; Dean Guo

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 132 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02078-6

✦ Synopsis

The biotransformation of cinobufagin by cell suspension cultures of Catharanthus roseus was investigated. After 6 days incubation, four new glucosylated derivatives, desacetylcinobufagin 16-O-b-D-glucoside, 3-epi-desacetylcinobufagin 16-O-b-D-glucoside, 3-oxo-desacetylcinobufagin 16-O-b-D-glucoside, and cinobufagin 3-O-b-D-glucoside, respectively, were isolated and identified on the basis of their physical and chemical data. This is the first report of bufadienolides with a glucosyl substituent at the C-16 position.