Regioselective hydroxylation of warfarin by cell suspension cultures of Catharanthus roseus
โ Scribed by Hiroki Hamada; Yoshihiro Fuchikami; Robert L. Jansing; Laurence S. Kaminsky
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 234 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0031-9422
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The effect of arsenic compounds on indole alkaloid production by cell suspension cultures of Catharanthus roseus was investigated. The analysis of indole alkaloids was achieved by using thermospray liquid chromatography-mass spectrometry (LC MS) which facilitated the rapid screening of alkaloid comp
Cathurunthus roseus cells were grown in the presence of arsenite, arsenate, methylarsonate and dimethylarsinate. Cell growth and arsenical uptake were monitored. Reduction of arsenate, methylation of arsenic and demethylation of methylarsenic species are described. Alkaloid production by the cells i