Glucosylated albumin and its influence on salicylate binding
β Scribed by K. A. Mereish; H. Rosenberg; J. Cobby
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 424 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0022-3549
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The influence of glycosylation on the drug binding of human serum albumin (HSA) was studied using HSA containing different amounts and degrees of glycosylated HSA. The drugs used were furosemide, naproxen, procaine, phenylbutazone, salicylic acid, sulphamethoxazole, tolbutamide and warfarin. The dru
## Abstract When drugβprotein binding data are evaluated thermodynamically standard free energy (ΞGΒ°), standard enthalpy (ΞHΒ°) and standard entropy (ΞSΒ°) are usually estimated from association constants __(K__~a~) derived from binding data obtained at only two temperatures. Estimation of ΞHΒ° involv