Glucose transporter glut 5 expression in microglial cells

✍ Scribed by Jennifer Payne; Fran Maher; Ian Simpson; Linda Mattice; Peter Davies

• Book ID: 101262773
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 298 KB
• Volume: 21
• Category: Article
• ISSN: 0894-1491
• DOI: 10.1002/(sici)1098-1136(199711)21:3<327::aid-glia7>3.0.co;2-1

✦ Synopsis

Glut 5 is a member of a family of facilitative glucose transporter proteins that are involved in the transportation of glucose and/or fructose across plasma membranes. Glut 5 is one of three isoforms expressed in brain. Using immunocytochemical and immunoblotting techniques in formalin fixed tissue, we have shown that Glut 5 is exclusively expressed in microglial cells of the human and rat brain. Our data demonstrate that unlike other microglial markers, Glut 5 can be used as a microglial marker in formalin fixed tissue.