Glucose-dependent insulinotropic polypeptide receptor (GIPR) polymorphism, bone phenotypes and obesity
✍ Scribed by J. Kumar; F. McGuigan; M. Callreus; M. Gomez; L. Groop; V. Lyssenko; K. Åkesson
- Book ID
- 116323280
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 55 KB
- Volume
- 47
- Category
- Article
- ISSN
- 8756-3282
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## Abstract Glucose‐dependent insulinotropic polypeptide (GIP) was initially described to be rapidly regulated by endocrine cells in response to nutrient ingestion, with stimulatory effects on insulin synthesis and release. Previously, we demonstrated a significant up‐regulation of GIP mRNA in the
Studies were carried out in 32 obese patients and 30 normal-weight control subjects to ascertain the response of glucose-dependent insulinotropic polypeptide (GIP) and insulin to (1) oral and intravenous glucose (10 obese and 10 control subjects), (2) oral fat and intravenous glucose (eight obese an