Glucosamine enhanced sperm-egg binding but inhibited sperm-egg fusion in mouse
โ Scribed by M. Okabe; M. Yagasaki; S. Matzno; M. Nagira; Y. Kohama; T. Mimura
- Book ID
- 105411650
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 599 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1420-682X
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Effects of various sulfhydryl (SH)-depleting reagents on sperm-egg fusion were demonstrated. When sperm were treated with three plasma membrane-permeable SH-depleting reagents, N-ethyl-maleimide, sodium tetrathionate and 5,5ยด-dithiobis (2-nitro-benzoic acid), the rates of cleavage of eggs were signi
## Abstract Sperm penetration of zonae and fertilization of mouse eggs in vitro was studied as a function of sperm concentration over the range 10^3^โ10^6^ cells/ml. Maximal fertilization was obtained at 10^5^ sperm/ml with markedly reduced levels seen at lower concentrations. Eggs inseminated at l
The fertilin a and b genes (Ftna and Ftnb, respectively) encode a sperm surface heterodimer that functions in sperm-egg fusion. They are the first identified members of a large gene family coding for multidomain membrane proteins (ADAMs) that include A Disintegrin And Metalloprotease domain. In this