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Glucocorticoid receptor-mediated apoptosis: mechanisms of resistance in cancer cells

✍ Scribed by Schlossmacher, G.; Stevens, A.; White, A.

Book ID
120486251
Publisher
Bioscientifica
Year
2011
Tongue
English
Weight
211 KB
Volume
211
Category
Article
ISSN
0022-0795

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The application of glucocorticoids (GC') in human leukemia is based on apoptosis induction but is often hampered by GC resistance. To delineate resistance mechanisms, we examined 5 GC-resistant leukemic cell lines, termed CEM-C7.RI-R5, isolated from the GC-sensitive human acute-1-cell-leukemic line,