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Glucocorticoid enhances hypoxia- and/or transforming growth factor-β-induced plasminogen activator inhibitor-1 production in human proximal renal tubular cells

✍ Scribed by Hideki Kimura; Xuan Li; Kunio Torii; Toshiharu Okada; Kazuko Kamiyama; Daisuke Mikami; Kenji Kasuno; Naoki Takahashi; Haruyoshi Yoshida

Publisher
Springer
Year
2010
Tongue
English
Weight
475 KB
Volume
15
Category
Article
ISSN
1342-1751

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The effects were examined of baicalein on tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) production stimulated by interleukin-1␣ (IL-1␤) and tumour necrosis factor-␣ (TNF-␣) in cultured human vein umbilical endothelial cells (HUVECs). IL-1␤ and TNF-␣ increased