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Glucocorticoid Attenuates the Anabolic Effects of Parathyroid Hormone on Fracture Repair

✍ Scribed by Anthony R. Doyon; Ian K. Ferries; Jiliang Li

Publisher
Springer
Year
2010
Tongue
English
Weight
598 KB
Volume
87
Category
Article
ISSN
1432-0827

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## Abstract Secreted frizzled‐related protein (sFRP)‐1 is a Wnt antagonist that when deleted in mice leads to increased trabecular bone formation in adult animals after 13 weeks of age. Treatment of mice with parathyroid hormone (PTH) also increases trabecular bone formation, and some of the anabol