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GLP-1 amplifies insulin signaling by up-regulation of IRβ, IRS-1 and Glut4 in 3T3-L1 adipocytes

✍ Scribed by Hong Gao; Xinjun Wang; Zhiguo Zhang; Yisheng Yang; Jun Yang; Xiaoying Li; Guang Ning

Book ID
118300348
Publisher
Springer
Year
2007
Tongue
English
Weight
301 KB
Volume
32
Category
Article
ISSN
0969-711X

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We tested the hypothesis that the constitutive glucose transporter (GLUT1) in 3T3-L1 adipocytes belongs to the family of glucose-regulated proteins which are transcriptionally regulated by glucose deprivation. Using cDNA probes for both GRP78 (BiP) and GLUT1, we show that the level of GRP78 mRNA inc