Global changes to the ubiquitin system in Huntington's disease
β Scribed by Bennett, Eric J.; Shaler, Thomas A.; Woodman, Ben; Ryu, Kwon-Yul; Zaitseva, Tatiana S.; Becker, Christopher H.; Bates, Gillian P.; Schulman, Howard; Kopito, Ron R.
- Book ID
- 109896832
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 453 KB
- Volume
- 448
- Category
- Article
- ISSN
- 0028-0836
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## Abstract Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disease caused by an abnormally expanded CAG repeat in the HD gene. Ubiquitylated aggregates containing mutant huntingtin protein in neurons are hallmarks of HD. Misfolded mutant huntingtin monomers, oligom
obtained his academic degree in 1983 from the Faculty of Pharmacy at the University of Barcelona. He then undertook his Doctorate at the Consejo Superior de Investigaciones CientΓficas in Barcelona working on the role of protein kinase C and lipid metabolism in multi-drug resistance. At present he i