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Glial cell line-derived neurotrophic factor promotes olfactory ensheathing cells migration

โœ Scribed by Li Cao; Zhida Su; Qiang Zhou; Baolai Lv; Xiujie Liu; Li Jiao; Zhihua Li; Yanling Zhu; Zhihui Huang; Aijun Huang; Cheng He

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
637 KB
Volume
54
Category
Article
ISSN
0894-1491

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โœฆ Synopsis

Abstract

Olfactory ensheathing cells (OECs) are a unique type of macroglia with axonal growthโ€promoting properties. The migrating ability of OECs in CNS is essential for neural regeneration. However, little is known about the extracellular and intracellular factors that regulate OEC migration. In the present study, we examined the effects of glial cell lineโ€derived neurotrophic factor (GDNF) on OECs migration. Initially, the โ€œscratchโ€ migration assay, Boyden chamber assay, and explant migration assay showed that GDNF could promote OECs migration in vitro. Treatment of OECs with GDNF also induced cytoskeleton reorganization and upโ€regulated expression of cytoskeleton proteins. GDNFโ€induced OECs migration was demonstrated depending on GFRฮฑโ€1 and Ret receptor, and activation of JNK and Src signaling cascades. Furthermore, GDNF was found to promote implanted OECs migration in a spinal cord hemisection injury model. Together, we report, to our knowledge for the first time, that GDNF stimulate OECs migration in vitro and in vivo. ยฉ 2006 Wileyโ€Liss, Inc.

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