Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor for sensory neurons: Comparison with the effects of the neurotrophins

✍ Scribed by Matheson, Christine R. ;Carnahan, Josette ;Urich, Janal L. ;Bocangel, Dora ;Zhang, T. J. ;Yan, Qiao

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 295 KB
• Volume: 32
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(199701)32:1<22::aid-neu3>3.0.co;2-g

✦ Synopsis

We compared the effects of glial cell 3 did not promote any detectable level of neuronal line-derived neurotrophic factor (GDNF) on dorsal survival despite the fact that they underwent retroroot ganglion (DRG) sensory neurons to that of nerve growth factor (NGF), brain-derived neurotrophic grade transport. We examined the in vitro survivalfactor (BDNF), and neurotrophin 3 (NT-3). All of promoting ability of these factors on neonatal DRG these factors were retrogradely transported to subneuronal cultures derived from neonatal rats. GDNF, populations of sensory neuron cell bodies in the L4/ NGF, and NT-3 were effective in vitro, while BDNF L5 DRG of neonatal rats. The size distribution of 125 Iwas not. The range of effects seen in the models de-GDNF-labeled neurons was variable and consisted of scribed here underscores the importance of testing both small and large DRG neurons (mean of 506.60 neuronal responsiveness in more than one model. The mm 2 ). 125 I-NGF was preferentially taken up by small biological responsiveness of DRG neurons to GDNF neurons with a mean cross-sectional area of 383.03 in multiple models suggests that this factor may play mm 2 . Iodinated BDNF and NT-3 were transported by a role in the development and maintenance of sensory medium to large neurons with mean sizes of 501.48 neurons.