Glial cell line-derived neurotrophic factor (GDNF): a drug candidate for the treatment of Parkinson’s disease
✍ Scribed by R. Grondin; Don M. Gash
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 85 KB
- Volume
- 245
- Category
- Article
- ISSN
- 0340-5354
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Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects approximately 1,000,000 Americans. The cause of the disease remains unknown. The histopathological hallmarks of the disease are dopaminergic striatal insufficiency secondary to a loss of dopaminergic neurons in the sub
We compared the effects of glial cell 3 did not promote any detectable level of neuronal line-derived neurotrophic factor (GDNF) on dorsal survival despite the fact that they underwent retroroot ganglion (DRG) sensory neurons to that of nerve growth factor (NGF), brain-derived neurotrophic grade tra
## Abstract ## Background: Glial cell‐derived neurotrophic factor is a survival factor for dopaminergic neurons and a promising candidate for the treatment of Parkinson's disease. However, the delivery issue of the protein to the brain still remains unsolved. Our aim was to investigate the effect