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Gli superfamily members in left–right patterning

✍ Scribed by Shuyun Wang; Jennifer Purnell; Stephanie M. Ware


Book ID
116975767
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
64 KB
Volume
295
Category
Article
ISSN
0012-1606

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Role of asymmetric signals in left-right
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Left±right asymmetric signaling molecules in mammals include three transforming growth factor b (TGFb)-related factors, Nodal, Lefty1 and Lefty2. They are all expressed on the left half of developing mouse embryos. Nodal acts as a left-side determinant by transducing signals through Smad and FAST an