GilR, an Unusual Lactone-Forming Enzyme Involved in Gilvocarcin Biosynthesis

✍ Scribed by Madan Kumar Kharel; Pallab Pahari; Hui Lian; Jürgen Rohr

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 193 KB
• Volume: 10
• Category: Article
• ISSN: 1439-4227
• DOI: 10.1002/cbic.200900130

✦ Synopsis

Abstract

Last at last: The terminal step of the gilvocarcin V (GV) biosynthetic pathway is an unusual lactone formation. Here we show that the enzyme, GilR, dehydrogenates the hemiacetal moiety of pregilvocarcin V to the lactone found in GV by using covalently bound FAD.magnified image