GilR, an Unusual Lactone-Forming Enzyme
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Madan Kumar Kharel; Pallab Pahari; Hui Lian; Jürgen Rohr
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Article
📅
2009
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John Wiley and Sons
🌐
English
⚖ 193 KB
## Abstract **Last at last**: The terminal step of the gilvocarcin V (GV) biosynthetic pathway is an unusual lactone formation. Here we show that the enzyme, GilR, dehydrogenates the hemiacetal moiety of pregilvocarcin V to the lactone found in GV by using covalently bound FAD.magnified image