Giant platelet granules in a child with the chediak-higashi syndrome
β Scribed by R. T. Parmley; M.-C. Poon; W. M. Crist; A. Malluh
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 762 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0361-8609
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## Abstract Cats with the ChediakβHigashi (CH) syndrome have abnormal hemostasis with prolonged bleeding times and normal coagulation times. Platelet aggregation induced by serotonin, ADP, and collagen was impaired. Platelets from normal and CH cats were incubated with ^14^Cβadenine and then gelβfi
Bleeding times, concentrations of serotonin in whole blood, and concentrations of adenine nucleotides as well as aggregation properties of platelets were examined in 18 blue foxes with Chediak-Higashi-like syndrome (CHS) and 16 controls. A claw of each ketamine-sedated fox was cut until bleeding sta