## Abstract Cats with the ChediakโHigashi (CH) syndrome have abnormal hemostasis with prolonged bleeding times and normal coagulation times. Platelet aggregation induced by serotonin, ADP, and collagen was impaired. Platelets from normal and CH cats were incubated with ^14^Cโadenine and then gelโfi
Deficiency of inducible suppressor cell activity in the Chediak-Higashi syndrome
โ Scribed by Madhavan P. N. Nair; Robert H. Gray; Laurence A. Boxer; Stanley A. Schwartz
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 794 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0361-8609
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Chediak-Higashi syndrome (CHS) is an auto-soma1 recessive disease in humans, cats, and 8 other species. The homology of CHS in humans and cats has been demonstrated. Since human CHS is a progressive, serious, and eventually fatal disease, a method for prenatal diagnosis would be desirable. This stud
ChediakโHigashi syndrome in Japanese black cattle is a hereditary disease with prolonged bleeding time and partial albinism. In the present study, we mapped the locus responsible for the disease (__CHS__) by linkage analysis using microsatellite genotypes of paternal halfโsib pedigrees obtained from