Giant Cell Tumor of the Larynx: A Case of Malignant Sarcomatous Transformation

✍ Scribed by Richard J. Vivero; Sandeep Dave; Donald T. Weed

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 629 KB
• Volume: 119
• Category: Article
• ISSN: 0023-852X
• DOI: 10.1002/lary.20380

✦ Synopsis

Objectives:

(1) To review the epidemiology, pathophysiology, and treatment of giant cell tumor of the larynx (2) To report the first case of malignant transformation of giant cell tumor of the larynx Methods: A case of giant cell tumor of the larynx from a tertiary care university teaching hospital is presented, including the patient's clinical course and subsequent treatment. The case is discussed within the context of a review of the current literature regarding this disease entity. To our knowledge, this report represents the first case of malignant transformation of giant cell tumor of the larynx.

Results:

The patient underwent hemilaryngopharyngectomy with radial forearm free flap reconstruction and eleven of fifteen cycles of chemotherapy. He remains disease free at approximately 36 months follow-up. The patient is decannulated and continues to have a good voice with excellent quality of life to this day. Conclusion: Our experience demonstrates that giant cell tumor of the larynx may present as a malignant neoplasm without adversely affecting the patient's prognosis when treated aggressively with surgical resection and adjunct chemotherapy.