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Ghrelin and the growth hormone secretagogue receptor in growth and development

✍ Scribed by Chanoine, J-P; De Waele, K; Walia, P


Book ID
109866421
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
98 KB
Volume
33
Category
Article
ISSN
1476-5497

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The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating