## Communicated by Georgia Chenevix-Trench Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited predisposition to colorectal cancer, which is caused by germline mutations in the adenomatous polyposis coli (APC) gene. The APC mutations have been investigated in 46 Czech unrelat
Germline mutations of the APC gene in two Japanese adenomatous polyposis patients
β Scribed by Yoshinori Nimura; Chizumi Furuwatari; Minoru Fujimori; Yoshiro Fujimori; Shinji Nakata; Ken-ichi Ito; Yoshihisa Hama; Kiyoshi Shingu; Wataru Adachi; Yoshifumi Ogiso; Ken-ichi Furihata; Tsutomu Katsuyama; Jun Amano
- Book ID
- 110676785
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 381 KB
- Volume
- 42
- Category
- Article
- ISSN
- 1435-232X
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Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra-colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline D N A of 81 unrelated FAP patients and evalua
Several investigators have reported germline mutations of the APC gene in patients with familial adenomatous polyposis (FAP) as well as somatic mutations in tumors developed in digestive organs (stomach, pancreas, colon, and rectum). Those results provide evidence that inactivation of the APC gene p
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm