In order to evaluate the role of BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer, 97 patients with sporadic breast cancer were analyzed for mutations in the BRCA1 and BRCA2 coding regions, by using a combination of fluorescent-conformation sensitive gel electrophore
Germline Mutations of BRCA1 and BRCA2 in Korean sporadic ovarian carcinoma
โ Scribed by Young Tae Kim; Eun Ji Nam; Bo Sung Yoon; Sang Wun Kim; Sung Hoon Kim; Jae Hoon Kim; Hyun Ki Kim; Ja Seong Koo; Jae Wook Kim
- Book ID
- 113960054
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 139 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0090-8258
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๐ SIMILAR VOLUMES
Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2
Previous mutational analysis for BRCA gene mutations in sporadic ovarian cancer occurring in Chinese patients in Hong Kong identified six germline BRCA1 mutations and one germline BRCA2 mutation, six of which were novel (Khoo et al., 2000). Knowledge of BRCA gene mutations in the Chinese population