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Germline BRCA2 mutations and the risk of esophageal squamous cell carcinoma

✍ Scribed by Akbari, M R; Malekzadeh, R; Nasrollahzadeh, D; Amanian, D; Islami, F; Li, S; Zandvakili, I; Shakeri, R; Sotoudeh, M; Aghcheli, K

Book ID: 110072728
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 153 KB
Volume: 27
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1210739

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## Abstract Recent studies of various cancers, such as those of the breast, head and neck, bladder and lung, reported that 46–64% of somatic mutations in the D‐loop region of mitochondrial DNA (mtDNA) are observed. However, in esophageal cancer, only a low rate (5%) of somatic mutations has so far