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Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

โœ Scribed by Robertson, Elizabeth; Bradley, Allan; Kuehn, Michael; Evans, Martin


Book ID
109747076
Publisher
Nature Publishing Group
Year
1986
Tongue
English
Weight
515 KB
Volume
323
Category
Article
ISSN
0028-0836

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## Abstract ## Background The use of retroviral vectors has shown an actual clinical benefit in a few inherited diseases. However, the occurrence of cases of leukemia after the Xโ€SCID gene therapy trial raised concerns about the safety of insertional mutagenesis inherent to the biology of the retr