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Germ-line P53 mutations and Li-Fraumeni syndrome

✍ Scribed by Brugières, L.; Bressac, B.; Bonaïti-Pellié, C.; Lemerie, J.; Feunteun, J.


Book ID
122674269
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
180 KB
Volume
29
Category
Article
ISSN
0959-8049

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Germline TP53 mutations and Li-Fraumeni
✍ J.M. Varley 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB

There are now reports of nearly 250 independent germline TP53 (p53) mutations in over 100 publications. Such mutations are typically associated with Li-Fraumeni or Li-Fraumeni-like syndrome, although many have been identified in cohorts of patients with tumors considered to be typical of LFS. In gen