Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways

✍ Scribed by Su-Hwa Kim; Hyun Cheol Bae; Eun-Jung Park; Chae Ryun Lee; Byung-Joo Kim; Sanghoon Lee; Hyun Ho Park; Sung-Joon Kim; Insuk So; Tae Woo Kim; Ju-Hong Jeon

• Book ID: 116301511
• Publisher: Elsevier Science
• Year: 2011
• Tongue: English
• Weight: 382 KB
• Volume: 407
• Category: Article
• ISSN: 0006-291X
• DOI: 10.1016/j.bbrc.2011.02.124

✦ Synopsis

The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer.