The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate
โฆ LIBER โฆ
Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways
โ Scribed by Su-Hwa Kim; Hyun Cheol Bae; Eun-Jung Park; Chae Ryun Lee; Byung-Joo Kim; Sanghoon Lee; Hyun Ho Park; Sung-Joon Kim; Insuk So; Tae Woo Kim; Ju-Hong Jeon
- Book ID
- 116301510
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 382 KB
- Volume
- 407
- Category
- Article
- ISSN
- 0006-291X
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Polypeptide growth factors are positive and negative regulators of prostatic growth and function, and many positive regulators of growth in the prostate have been extensively studied. However, very few inhibitors of prostate cell proliferation have been identified. We have isolated a unique 18-kDa s