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Geometry of DNA–dye intercalation complexes from the study of linear dichroic spectra of stretched films

✍ Scribed by Gregory R. Kelly; Tomas Kurucsev

Book ID
102764744
Publisher
Wiley (John Wiley & Sons)
Year
1976
Tongue
English
Weight
555 KB
Volume
15
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Films of DNA–dye complexes were combined with films of pure DNA deposited on poly(vinyl alcohol) support and stretched. Reproducible dichroic spectra were obtained after equilibration of the stretched films at 93% relative humidity. Dye diffusion into the supporting poly(vinl alcohol) matrix was eliminated. The long axis of intercalated acriflavine is perpendicular to the DNA helix; proflavine deviates slightly and 9‐aminoacridine significantly from such an intercalation geometry. The dichroism of two mutually perpendicularly polarized transitions of 9‐aminoacridine enabled us to determine both the angles of tilt and twist of the plane of the dye relative to the DNA helix in the complex.

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