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Genotypic and haplotypic associations of the DBH gene with plasma dopamine β-hydroxylase activity in African Americans

✍ Scribed by Tang, Yi-lang; Epstein, Michael P; Anderson, George M; Zabetian, Cyrus P; Cubells, Joseph F

Book ID: 110027038
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 116 KB
Volume: 15
Category: Article
ISSN: 1018-4813
DOI: 10.1038/sj.ejhg.5201838

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## Abstract The __DBH__ locus controls plasma dopamine β‐hydroxylase activity (pDβH). A 5′‐upstream single nucleotide polymorphism (SNP) at __DBH__ (−1021C → T) explains ∼45% of the variance in pDβH, and a non‐synonymous SNP in exon 11 (+ 1603C → T) an additional 2%. However, that regression result