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A haplotype at the DBH locus, associated with low plasma dopamine β-hydroxylase activity, also associates with cocaine-induced paranoia

✍ Scribed by Cubells, J F; Kranzler, H R; McCance-Katz, E; Anderson, G M; Malison, R T; Price, L H; Gelernter, J

Book ID: 110059137
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 164 KB
Volume: 5
Category: Article
ISSN: 1359-4184
DOI: 10.1038/sj.mp.4000657

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## Abstract The __DBH__ locus controls plasma dopamine β‐hydroxylase activity (pDβH). A 5′‐upstream single nucleotide polymorphism (SNP) at __DBH__ (−1021C → T) explains ∼45% of the variance in pDβH, and a non‐synonymous SNP in exon 11 (+ 1603C → T) an additional 2%. However, that regression result