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Genotype-controlled analysis of plasma dopamine β-hydroxylase activity in psychotic unipolar major depression

✍ Scribed by Joseph F. Cubells; Lawrence H. Price; Barnett S. Meyers; George M. Anderson; Cyrus P. Zabetian; George S. Alexopoulos; J.Craig Nelson; Gerard Sanacora; Paul Kirwin; Linda Carpenter; Robert T. Malison; Joel Gelernter


Book ID
119408751
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
105 KB
Volume
51
Category
Article
ISSN
0006-3223

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## Abstract The __DBH__ locus controls plasma dopamine β‐hydroxylase activity (pDβH). A 5′‐upstream single nucleotide polymorphism (SNP) at __DBH__ (−1021C → T) explains ∼45% of the variance in pDβH, and a non‐synonymous SNP in exon 11 (+ 1603C → T) an additional 2%. However, that regression result