Genotype and phenotype in hereditary nonpolyposis colon cancer: a study of families with different vs. shared predisposing mutations
✍ Scribed by Päivi Peltomäki; Xin Gao; Jukka-Pekka Mecklin
- Book ID
- 110303509
- Publisher
- Springer Netherlands
- Year
- 2001
- Tongue
- English
- Weight
- 243 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1389-9600
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📜 SIMILAR VOLUMES
Fourteen Italian families affected with hereditary nonpolyposis colorectal cancer (HNPCC) were screened for germline mutations at three DNA mismatch repair (MMR) genes, MSH2, MLH1, and GTBP, by using a combination of different methods that included an in vitro synthesized protein assay, single-stran
## Abstract ## BACKGROUND Hereditary nonpolyposis colorectal carcinoma (HNPCC) significantly raises the risk of developing colorectal carcinoma (CRC) and other extracolonic tumors. It is defined by the Amsterdam Criteria and is associated with germline mutations in mismatch repair genes, primarily