Genotoxicity of topoisomerase II inhibition is altered by changes in DNA methylation
β Scribed by I. Eckert; S. Kirchner; P. Wagener; H. Stopper
- Book ID
- 114133269
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 80 KB
- Volume
- 360
- Category
- Article
- ISSN
- 0165-1161
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Adriamycin is commonly used as a chemotherapeutic agent and is known to intercalate into the major groove of DNA and inhibit DNA and RNA synthesis. Results presented in this communication suggest that adriamycin affects topoisomerase cleavage of DNA. The resultant change in negative superhelicity (d
## Abstract Topoisomerases maintain the DNA structure by relieving the torsional stress and alleviating other topological problems occurring in DNA during transcription and replication. Topoisomerase II appears to have a close association with the family of proteins involved in the organization of