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Inhibition of DNA synthesis and DNA fragmentation in stimulated splenocytes by the concerted action of topoisomerase I and II poisons

✍ Scribed by Georges Taudou; Christiane Portemer; Christine Jaxel; Michel Duguet


Book ID
115783179
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
835 KB
Volume
45
Category
Article
ISSN
0006-2952

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Insulin-like growth factor binding protein-5 (IGFBP-5) is synthesized and secreted by smooth muscle cells (SMC). IGFBP-5 synthesis is stimulated five-to sixfold by IGF-I, and IGFBP-5 has been shown to augment IGF-I-stimulated DNA synthesis in this cell type. The ability of IGFBP-5 to augment the SMC