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Genotoxicity of lavender oil, linalyl acetate, and linalool on human lymphocytes in vitro

✍ Scribed by Antonella Di Sotto; Gabriela Mazzanti; Fabio Carbone; Patrizia Hrelia; Francesca Maffei

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 69 KB
Volume: 52
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.20587

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✦ Synopsis

Abstract

The potential genotoxicity of lavender essential oil and its major components, linalool, and linalyl acetate, was evaluated in vitro by the micronucleus test on peripheral human lymphocytes. In the range of non‐toxic concentrations (0.5–100 μg/ml), linalyl acetate increased the frequency of micronuclei significantly and in concentration‐dependent manner; lavender oil did so only at the highest concentration tested, whereas linalool was devoid of genotoxicity. None of the tested substances led to an increase in nucleoplasmic bridges or nuclear buds frequency. These findings suggest that the mutagenic activity of lavender oil can be related to the presence of linalyl acetate, which seems to have a profile of an aneugenic agent. Environ. Mol. Mutagen. 52:69–71, 2011. © 2010 Wiley‐Liss, Inc.

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