Studies on the genotoxicity of molybdenum salts in human cells in vitro and in mice in vivo

✍ Scribed by Nina Titenko-Holland; Jianhua Shao; Luoping Zhang; Liqiang Xi; Hailong Ngo; Nong Shang; Martyn T. Smith

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 164 KB
• Volume: 32
• Category: Article
• ISSN: 0893-6692
• DOI: 10.1002/(sici)1098-2280(1998)32:3<251::aid-em8>3.0.co;2-r

✦ Synopsis

Molybdenum is an essential element in plants and observed. Based on the results of a toxicity study of animals as a cofactor for enzymes. Molybdenum sodium molybdate, two doses, 200 and 400 mg/ trioxide is used in metallurgical processes, in cos-kg, were assessed in the bone marrow MN assay metics as a pigment, and in contact lens solution, in mice (two i.p. injections 24 and 48 hr prior to yet limited information is available on molybdenum euthanasia). A modest but statistically significant ingenotoxicity. In the present study the micronucleus crease in MN frequency in polychromatic erythro-(MN) assay in human lymphocytes and mouse bone cytes was observed (P õ 0.05). The same treatment marrow and the dominant lethal assay in mice were protocol was used to analyze dominant lethality. A used to assess the genotoxic effects of molybdenum dose-dependent increase in postimplantation loss salts in vitro and in vivo. Two salts of molybdenum represented mostly by early resorptions was obwere tested in whole blood cultures. Ammonium mo-served the first week after treatment (P Å 0.003). lybdate was more potent than sodium molybdate in These preliminary data suggest that sodium molybcausing a dose-dependent decrease in viability and date induces dominant lethality at the postmeiotic replicative index and an increase in MN formation stage of spermatogenesis. Overall, molybdenum in binucleated lymphocytes (P õ 0.001). A dose -salts produced moderately positive results both in vitro response in both kinetochore-positive MN (caused in human cells and in vivo in mice. Environ. Mol. Mutaby chromosome lagging) and kinetochore-negative gen. 32: 251-259, 1998 ᭧