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Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay

โœ Scribed by Park, Margriet V. D. Z.; Verharen, Henny W.; Zwart, Edwin; Hernandez, Lya G.; van Benthem, Jan; Elsaesser, Andreas; Barnes, Clifford; McKerr, George; Howard, C. Vyvyan; Salvati, Anna


Book ID
111674623
Publisher
Informa plc
Year
2010
Tongue
English
Weight
630 KB
Volume
5
Category
Article
ISSN
1743-5390

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## Abstract The mutagenic potential of zinc pyrithione (Znpt) was evaluated __in vitro__ in the __Salmonella__/mammalian microsome plate incorporation mutagenicity (Ames) assay and the CHO/HGPRT gene mutation assay. The clastogenic potential of Znpt was evaluated __in vivo__ using the mouse micronu