Genomic Structure of the Human Retinoblastoma-Related Rb2/p130 Gene
β Scribed by Alfonso Baldi, Vincenzo Boccia, Pier Paolo Claudio, Antonio De Luca and Antonio Giordano
- Book ID
- 123639674
- Publisher
- National Academy of Sciences
- Year
- 1996
- Tongue
- English
- Weight
- 740 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/38826
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## Abstract Reduced expression of the retinoblastoma gene (RB)2/p130 protein, as well as mutation of exons 19, 20, 21, and 22 of the same gene, has been reported in primary lung cancer. However, it has been suggested by other investigators that mutational inactivation and loss of the __RB2__/__p130
## Abstract Alteration of the retinoblastomaβrelated gene __RB2/p130__ was investigated in lung adenocarcinomas induced by __N__βnitrosobis(2βhydroxypropyl)amine (BHP) in male Wistar rats. At 6 wk of age, 21 animals were given 2000 ppm of BHP in their drinking water for 12 wk and then maintained wi