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Genomic organization and 5′ regulatory region of the mouse IL-2 receptor β-chain gene (IL-2Rb)

✍ Scribed by E. K. Codias; Ferenc Olosz; Thomas R. Malek


Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
202 KB
Volume
51
Category
Article
ISSN
0093-7711

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A functional high-affinity IL-2 receptor (IL-2R) is comprised of at least three subunits (cz, [3, and 7) that cooperatively act to bind IL-2, leading to the growth of antigen-activated T lymphocytes (Hatakeyama et al. 1989;Takeshita et al. 1992). Mouse and human IL-2Rc~ chain genes (I1-2ra) have bee