Genomic Loss of Heterozygosity (LOH) in Pediatric Ovarian Germ Cell Tumors (OGCT)
β Scribed by Maxine J. Sutcliffe; Rudolfo Ortega; Doris P. Dumont; Hardeo Panchoosingh; Samuel Laden
- Book ID
- 116332708
- Publisher
- Elsevier
- Year
- 2012
- Tongue
- English
- Weight
- 37 KB
- Volume
- 205
- Category
- Article
- ISSN
- 2210-7762
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## BACKGROUND. Insulin-like growth factor-2 (IGF2) and H19 are reciprocally imprinted genes on chromosome 11; IGF2 is expressed paternally and H19 is expressed maternally. Loss of imprinting (LOI) at both H19 and IGF2 has been reported in seven fully informative adult testicular germ cell tumors (
To identify common regions of deletion in human testicular germ cell tumors (TGCTs), we have screened tumors from 33 patients for loss of heterozygosity (LOH) using Southern blot analysis with 39 polymorphic markers covering 21 chromosome arms. Losses in more than 2 tumors and occurring at a frequen