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Genomic imprinting in ruminants: allele-specific gene expression in parthenogenetic sheep

✍ Scribed by Robert Feil, Sanjeev Khosla, Pietro Cappai, Pasqualino Loi


Book ID
113034860
Publisher
Springer-Verlag
Year
1998
Tongue
English
Weight
190 KB
Volume
9
Category
Article
ISSN
0938-8990

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The insulin-like growth factor II (IGF2) gene is imprinted with the paternal allele expressed and the maternal one silent. Loss of imprinting (LOI) of IGF2 has been suggested to play a role in the development of tumours, but the reported incidence of IGF2 LOI in tumours shows considerable variation,