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Genomic imprinting determines methylation of parental alleles in transgenic mice

โœ Scribed by Reik, Wolf; Collick, Andrew; Norris, Michael L.; Barton, Sheila C.; Surani, M. Azim

Book ID
109750034
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
534 KB
Volume
328
Category
Article
ISSN
0028-0836

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## Abstract It is demonstrated that a heterologous (chicken) CpG island containing five Sp1 canonical recognition sequences becomes highly methylated in the genome of transgenic mice bearing one or several copies of the transgene. Similar levels of methylation of the chicken CpG island were observe