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Genomic changes in glioblastoma cell lines detected by comparative genomic hybridization

✍ Scribed by Vijayanagaram S. Venkatraj; Martin Begemann; Antonio Sobrino; Jeffrey N. Bruce; I. Bernard Weinstein; Dorothy Warburton

Book ID
110229903
Publisher
Springer US
Year
1998
Tongue
English
Weight
461 KB
Volume
36
Category
Article
ISSN
0167-594X

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Compaative genomic hybridization (CCH) is a recent molecular cytogenetic method that detects and localizes gains or losses in DNA copy number across the entire tumor genome. We used CGH to examine 9 glioma cell lines and 20 primary and 10 recurrent glioblastoma tumors. More than 25% of the primary t