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Genomic alterations in human breast carcinomas

✍ Scribed by Dr. Catharina Larsson; Camilla Byström; Lambert Skoog; Sam Rotstein; Magnus Nordenskjöld

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
588 KB
Volume
2
Category
Article
ISSN
1045-2257

No coin nor oath required. For personal study only.

✦ Synopsis

All human chromosomes were screened in 52 human breast Carcinomas for the occurrence of allele losses, in order t o identify genomic alterations involved in initiation and progression of the disease. Loss of chromosome 22 alleles was detected in 6 out of 8 lobular carcinomas, while chromosome I 7 losses were most frequent in ductal carcinomas. Furthermore, patients who developed advanced disease after many years of mild clinical course showed significantly higher frequencies of allele losses in their primary tumors, compared t o patients with a persistently mild disease course. Finally, in one case, molecular examination suggested a translocation t( 10; 17) with coamplification of the ERBB2 oncogene and chromosome 10 sequences present in the two tumors from this patient, consistent with one of the tumors being a metastasis originating from a subclone of cells in the other tumor.

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