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FGF7 protein expression in human breast carcinomas

✍ Scribed by Jacquemier, Jocelyne; Sun, Zhen-zhu; Penault-llorca, Frédérique; Geneix, Jeanine; Devilard, Elizabeth; Adélaïde, José; Birnbaum, Daniel

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
251 KB
Volume
186
Category
Article
ISSN
0022-3417

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✦ Synopsis

FGFs, especially FGF7, are thought to play an important role in the stroma-epithelium interactions that take place in several tissues, including the prostate and mammary glands. Using an immunohistochemistry approach, FGF7 protein expression was measured in a series of 80 human breast carcinomas. FGF7 was found to be expressed in two-thirds of cases studied, either in the stroma or in the tumour cells. Although it did not reach significance level, a tendency was noted for FGF7 expression to be associated with the most differentiated and least aggressive tumours.

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