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Genome-Wide Localization of the Nuclear Transport Machinery Couples Transcriptional Status and Nuclear Organization

✍ Scribed by Jason M Casolari; Christopher R Brown; Suzanne Komili; Jason West; Haley Hieronymus; Pamela A Silver


Book ID
117269908
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
602 KB
Volume
117
Category
Article
ISSN
0092-8674

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## Abstract The temporal and spatial organization of transcriptional regulatory machinery provides microenvironments within the nucleus where threshold concentrations of genes and cognate factors facilitate functional interactions. Conventional biochemical, molecular, and in vivo genetic approaches