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Genomic organization, chromosomal localization and regulation of expression of the neuronal nuclear matrix protein NRP/B in human brain tumors

โœ Scribed by Tae-Aug Kim; Setsuo Ota; Shuxian Jiang; Linda M. Pasztor; Robert A. White; Shalom Avraham


Book ID
117519971
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
726 KB
Volume
255
Category
Article
ISSN
0378-1119

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Germline mutations in the von Hippel-Lindau (VHL) disease tumor suppressor gene (TSG) convey a high risk of clear-cell renal-cell carcinoma (CC-RCC) and most sporadic CC-RCCs demonstrate somatic inactivation of the VHL TSG. However, the existence of further CC-RCC gatekeeper genes is implied by CC-R