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Genome-Wide Association Study Confirms SNPs in SNCA and the MAPT Region as Common Risk Factors for Parkinson Disease

✍ Scribed by Todd L. Edwards; William K. Scott; Cherylyn Almonte; Amber Burt; Eric H. Powell; Gary W. Beecham; Liyong Wang; Stephan Züchner; Ioanna Konidari; Gaofeng Wang; Carlos Singer; Fatta Nahab; Burton Scott; Jeffrey M. Stajich; Margaret Pericak-Vance; Jonathan Haines; Jeffery M. Vance; Eden R. Martin


Book ID
111111536
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
175 KB
Volume
74
Category
Article
ISSN
0003-4800

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We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P ¼ 2.0 Â 10 -7 ) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further