Genome-wide association studies: the key to unlocking neurodegeneration?
โ Scribed by Gandhi, Sonia; Wood, Nicholas W
- Book ID
- 109938366
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 191 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1097-6256
- DOI
- 10.1038/nn.2584
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## Abstract Genomeโwide association studies employ hundreds of thousands of statistical tests to determine which regions of the genome may likely harbor diseaseโcausing alleles. Such largeโscale testing simultaneously requires stringent control over type I error and maintenance of sufficient power
## Abstract The large number of tests performed in analyzing data from genomeโwide association studies has a large impact on the power of detecting risk variants, and analytic strategies specifying the optimal set of hypotheses to be tested are necessary. We propose a genomeโwide strategy that is b